Evaluation of circulating endothelial progenitor cells in cardiovascular risk.

نویسندگان

  • Yasuyuki Fujita
  • Takayuki Asahara
چکیده

ndothelial progenitor cells (EPCs) are immature cells that have the capacity to proliferate, migrate, and differentiate into endothelial lineage cells. Embryological research has clarified that embryonic hematopoietic stem cells (HSCs) and EPCs are derived from a common precursor (ie, hemangioblast) and share many surface marker antigens such as Flk-1 (VEGFR2), Tie-2, c-Kit, Sca-1, AC133 (CD133), and CD34.1,2 In 1997, Asahara et al3 initially demonstrated that adult peripheral blood contains progenitors of endothelial cells by showing that CD34 antigen-positive (CD34+) mononuclear cells isolated from adult human peripheral blood could differentiate into an endothelial cell-like phenotype expressing many endothelial cell-specific markers in vitro. In animal models of ischemia, heterologous, homologous, and autologous EPCs were shown to incorporate into sites of active neovascularization. This finding was followed by diverse identifications of EPCs using equivalent or different methodologies by several groups.4–8 Because adult EPCs share many markers with HSCs as in the embryonic situation, no simple definition of EPCs by exactly specific marker expression exists. However, many studies have identified circulating EPCs (CPCs) by cell surface markers, such as CD34+, CD133+, VEGFR2+ or their combinations, to quantify the number of circulating EPCs.3,9

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عنوان ژورنال:
  • Circulation journal : official journal of the Japanese Circulation Society

دوره 75 11  شماره 

صفحات  -

تاریخ انتشار 2011